Bradley A. Saville

Bradley SavilleProfessor
B.Sc., Ph.D.(Alberta), P.Eng.

Management Co-Chair of Occupational Health and Safety, Dept. of Chemical Engineering & Applied Chemistry
Principal Investigator
Bioprocess Engineering Lab and
BioZone – Centre for Applied Bioscience and Bioengineering

Room: WB340 | Tel.: 416-978-7745 | Email: bradley.saville@utoronto.ca

Awards

Technology Innovator Award, University of Toronto, 2007

Undergraduate Teaching Award, University of Toronto, 1994

Memberships

Canadian Society for Chemical Engineering
Professional Engineers of Ontario
Ontario Society of Professional Engineers (OSPE)

Research Interests

Applications of Enzymes

Soluble and immobilized enzymes may find potential use in a variety of applications, including pharmaceutical production, pulp and paper processing, and wastewater treatment, to name a few. Research in this area is focused upon the development of applications of enzyme preparations, and the design and scale-up of reactors in which enzymes are used for specific industrial applications.

Biofuels and Bioenergy

Renewable energy sources such as ethanol, bio/renewable diesel and biogas are finding increased prominence, as we seek to supplement fossil fuels, reduce GHG emissions, and enhance the rural economy. Work in this area has focused on enzymes for conversion of starch and lignocellulosics into sugars, biofuels, and bioproducts, and upon biomass pretreatment methods needed to enhance enzyme hydrolysis of lignocellulosics. Also within this subject area, we aim to develop comprehensive process models of biofuel/bioenergy production systems, for the purposes of financial analysis and life cycle assessment.

Enzyme inactivation, inhibition and regulation of enzyme activity

Successful industrial use of enzymes is contingent upon the availability of a stable, low cost enzyme preparation. Some enzymes are subject to substrate-induced inactivation, whereby the exposure of the enzyme to a toxic substrate can lead to an irreversible loss of activity. The occurrence of inactivation and inhibition has significant implications upon industrial biochemical production and upon the sequential administration of drugs in humans. This work is aimed at investigating methods to improve enzyme function.

Drug distribution and elimination

In this research, fundamental principles in reaction kinetics and mass transfer are applied to develop a model of drug metabolism. The model is then used to determine drug/toxin distribution in organs such as the liver, kidney, or eyes. This may serve as a precursor to development and optimization of drug delivery systems. Current applications include the development a mathematical models of kidney dialysis.

Selected Publications

McKechnie, J., Zhang, Y., Ogino, A., Saville, B., Sleep, S., Turner, M., Pontius, P., MacLean, H.L., “Impacts of co-location, co-production and process energy source on life cycle energy use and greenhouse gas emissions of lignocellulosic ethanol”, Biofuels, Bioproducts & Biorefining, 2011

Porter, S., and Saville, B.A., “Biofuel Transportation and Distribution Options for APEC Economies”, Technical  Report for the Asia-Pacific Economic Cooperation Organization, May 2011 http://publications.apec.org/publication-detail.php?pub_id=1166

S. Di Risio, S., Hu, S., Saville, B.A., Liao, D., Lortie, J., “Large-Scale High-Solids Enzymatic Hydrolysis of Steam-Exploded Poplar”, Biofuels, Bioproducts & Biorefining, 2011

Sanscartier, D., MacLean, H., and Saville, B.A., “Techno-economic and greenhouse gas emissions evaluation of anaerobic digestion of household organic waste under Ontario’s Feed-in Tariff program”, Environmental Science and Technology, 2012

Hong, Y., Nizami, A-S., Pourbafrani, M., Saville, B.A., Maclean, H., “Impact of Cellulase Production on Environmental and Financial Metrics for Lignocellulosic Ethanol”, BIOFPR, April 2013

Pourbafrani, M., McKechnie, J., MacLean, H., and Saville, B.A., “Life Cycle Greenhouse Gas Impacts of Ethanol, Biomethane and Limonene production from Citrus Waste”, Environmental Research Letters, 8, 2013

Pourbafrani, M., McKechnie, J., MacLean, H., and Saville, B.A., “Bioplastic Products from Citrus Wastes”, Bioplastics Magazine, April 2013