Molly S. Shoichet

Molly Shoichet newUniversity Professor
B.Sc. (MIT), M.Sc., Ph.D. (Massachusetts)
Canada Research Chair in Tissue Engineering
Principal Investigator
Shoichet Lab
Room: 160 College Street, Room 514 | Tel: 416-978-1460 | Fax: 416-978-8287 | Email:molly.shoichet@utoronto.ca

Awards

  • Order of Canada, Officer, 2018
  • Killam Prize, Engineering, 2017
  • Foreign Member, US National Academy of Engineering, 2016
  • L’Oréal-UNESCO For Women in Science Laureate for North America, 2015
  • Senior Scientist Award, 2014 Tissue Engineering and Regenerative Medicine, Americas, 2014
  • University Professor, University of Toronto (<2% of faculty have this distinction), 2014
  • Queen Elizabeth II Diamond Jubilee Award, 2013
  • International Fellows of Tissue Engineering and Regenerative Medicine (FTERM), 2013
  • Fellow, Canadian Academy of Health Sciences, 2012-present
  • Fellow, Canadian Academy of Engineering, 2012-present
  • Fellow, Royal Society of Canada, 2008-present
  • Innovation of the Year Award, University of Toronto, 2012
  • Society for Biomaterials (USA), Clemson Award for Contributions to Literature, 2012
  • Order of Ontario, 2011
  • Fellow, American Association for the Advancement of Science (AAAS), 2011
  • Canada Council for the Arts Killam Research Fellowship. 2008-2010
  • Clara Benson Award, Canadian Society for Chemistry, 2009
  • Fellow, Biomaterials Science and Engineering (FBSE), 2008-present
  • Natural Sciences and Engineering Research Council: Steacie Fellowship, 2003-2005
  • Royal Society of Canada, Rutherford Memorial Medal in Chemistry, 2006
  • Canada Research Chair in Tissue Engineering, Tier I, 2006-2013; 2013-2019
  • Fellow, American Institute for Medical and Biological Engineering, 2006-present
  • UK-Canada WISET lectureship, Royal Society of Canada, 2005
  • McLean Award, University of Toronto, 2004
  • Canada Research Chair in Tissue Engineering, Tier II, 2001-2006
  • Canadian Society for Chemical Engineering: Syncrude Canada Innovation Award, 2003
  • Canada Foundation for Innovation: Career Award, 2003
  • Canadian Institute for Advanced Research, Young Explorer’s Award, 2002 (to top 20 researchers in Canada aged 40 and under)
  • Canada’s Top 40 under 40, 2001 (awarded 2002) – for innovation and leadership
  • Natural Sciences and Engineering Research Council: University Faculty Award, 1995-2000

Memberships

Tissue Engineering and Regenerative Medicine International Society, President Elect
American Chemical Society
Society for Biomaterials
Canadian Biomaterials Society
Chemical Institute of Canada
Society for Neuroscience

Research Interests

Biomaterials: Polymer Science for Tissue Engineering

Our research program requires a cross disciplinary approach where aspects of engineering, chemistry, and biology are applied to the fields of Regenerative Medicine, Tissue Engineering and Drug Delivery. We approach unsolved problems in biology and medicine by creating a series of design criteria which we then use to formulate solutions.

Our laboratory has designed novel injectable hydrogels for local delivery of biomolecules, stem cells and their progenitors to the injured spinal cord, brain and retina. We have created novel, stable colloidal drug aggregates and innovative targeting strategies for delivery in cancer. We have pursued tissue engineered 3-dimensional constructs comprised of novel hydrogels to control cell fate including spatial control of cell differentiation, using multiphoton laser excitation and advanced photochemistry Our laboratory is pursuing a diversity of projects, which are linked by the common theme of polymeric design to solve unanswered problems in biology.

Our multidisciplinary projects have collaborators with complementary expertise, in stem cell biology, neuroscience, neurosurgery and cancer. Our laboratory is funded primarily by the Natural Sciences and Engineering Council of Canada, the Canadian Institutes of Health Research, the Canada First Research Excellence Fund via Medicine by Design, the Krembil Foundation, McEwen Foundation, among others.

Targeted Delivery: We turned nuisance to nuance with the design of stable colloidal drug aggregates and investigated the power of click chemistry for antibody-mediated antisense oligonucleotide delivery in applications related to cancer.

Injectable Hydrogels: Using a physical blend of hyaluronan and methyl cellulose, we achieved local and sustained delivery of biomolecules to both the injured spinal cord and stroke-injured brain, demonstrating tissue and functional repair.

3-D Scaffolds: To better mimic the cellular microenvironment, we incorporated both haptotactic and chemotactic cues into 3-dimensional hydrogels using bio-orthogonal chemistry, photochemistry and multiphoton lasers. Haptotactic cues include cell adhesive proteins and peptides. Chemotactic cues include growth factors.

Cell Delivery: Two key challenges in stem cell transplantation are cell survival and cell integration. Through careful design of the environment in which cells are transplanted, we have achieved greater success in cell transplantation to the eye, brain and spinal cord for application in blindness, stroke and spinal cord injury, respectively.

Selected Publications

Pakulska M.M.; Miersch, S.; Shoichet, M.S. 2016 “Designer protein delivery: from natural occurring to engineered affinity controlled release systems”, Science, 351(6279):aac4750; doi: 10.1126/science.aac4750

Pakulska, M.M.; Elliott Donaghue, I.; Obermeyer, J.; Tuladhar, A.; McLaughlin, C.K.; Shoichet, M.S. 2016 “Encapsulation-free controlled release: electrostatic interactions eliminate the need for protein encapsulation in PLGA nanoparticles”, Science Advances, 2, e1600519 doi:10.1126/sciadv.1600519

Ganesh, A.N.; McLaughlin, C.K.; Duan, D.; Shoichet, B.K.; Shoichet, M.S. 2017 “A new spin on antibody-drug conjugates: trastuzumab-fulvestrant colloidal drug aggregates target HER2-positive cells”, ACS Applied Materials & Interfaces, 9: 12195-202; doi: 10.1021/acsami.6b15987

Fisher, S.A.; Tam, R.Y.; Fokina, A.; Mahmoodi, M.M.; Distefano, M.D.; Shoichet, M.S. 2018 “Photo-immobilized EGF chemical gradients differentially impact breast cancer cell invasion and drug response in defined 3D hydrogels” Biomaterials, in press xx1-x16; doi: 10.1016/j.biomaterials.2018.01.032

Arnold, A.E.; Malek-Adamian, E.; Lee, P.U.; Meng, A.; Martinez-Montero, S.; Petrecca, K.; Damha, M.J.; Shoichet, M.S. “Antibody-antisense oligonucleotide conjugate downregulates a key gene in glioblastoma stem cells”, Molecular Therapy – Nucleic Acids, 11: 518-27; doi: 10.1016/j.omtn.2018.04.004

Ballios, B.G.; Cooke, M.J.; Clarke, L.; Cole, B.; Morshead, C.M.; van der Kooy, D.; Shoichet, M.S. 2015 “A hyaluronan based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation” Stem Cell Reports, 4: 1031-45; doi: 10.1016/j.stemcr.2015.04.008