B. A. Saville
B.Sc., Ph.D.(Alberta), P.Eng.Tel.: 416-978-7745
Email: bradley.saville@utoronto.ca
Websites: chem-eng.utoronto.ca/~saville and www.biozone.utoronto.ca
Professional Engineers of Ontario
American Institute of Chemical Engineering
Technical Association of Pulp and Paper Industries (TAPPI)
Research Interests
Biochemical and Biomedical Engineering
Enzyme inactivation and regulation of enzyme activity
Some enzymes are subject to substrate-induced inactivation, whereby the exposure of the enzyme to a toxic substrate can lead to an irreversible loss of activity. Although inactivation has been frequently observed, the precise mechanism for the inactivation process is unknown. The occurrence of inactivation has significant implications upon industrial biochemical production and upon the sequential administration of drugs in humans. This work is aimed at developing means to reduce enzyme inactivation, and improve the performance of enzymes for biochemical production of drugs and other commodity chemicals.
Ocular adsorption, distribution, and elimination of drugs
In order to improve the delivery of drugs to the eye, it is necessary to understand how a drug is absorbed and distributed within the eye. In this project, fundamental principles in reaction kinetics and mass transfer will be applied in the development of a model of ocular drug metabolism. The model will subsequently be used to determine delivery profiles which may then be used to optimize the delivery of drugs to the eye.
S. Friedrich, B.A. Saville, Y-L. Cheng, D.S. Rootman, "Pharmacokinetic Differences between Ocular Inserts & Eyedrops", J. Ocul. Pharmacol. Ther., 12, 5-8 (1996).
C. Oh, A.J.G. Apel, B.A. Saville, Y-L. Cheng, D.S. Rootman, "Local Efficacy of Cyclosporine in Corneal Transplant Therapy", Current Eye Research, 13[5], 337-343, 1994.
R. Venugopal and B.A. Saville, "The Effect of Oxygen upon the Kinetics of Glucose Oxidase Inactivation", Can. J. Chem. Eng., 71, 917-924 (1993).
Email: bradley.saville@utoronto.ca
Websites: chem-eng.utoronto.ca/~saville and www.biozone.utoronto.ca
Awards
Undergraduate Teaching Award, 1994Memberships
Canadian Society for Chemical EngineeringProfessional Engineers of Ontario
American Institute of Chemical Engineering
Technical Association of Pulp and Paper Industries (TAPPI)
Research Interests
Biochemical and Biomedical Engineering Enzyme inactivation and regulation of enzyme activity
Some enzymes are subject to substrate-induced inactivation, whereby the exposure of the enzyme to a toxic substrate can lead to an irreversible loss of activity. Although inactivation has been frequently observed, the precise mechanism for the inactivation process is unknown. The occurrence of inactivation has significant implications upon industrial biochemical production and upon the sequential administration of drugs in humans. This work is aimed at developing means to reduce enzyme inactivation, and improve the performance of enzymes for biochemical production of drugs and other commodity chemicals.
Ocular adsorption, distribution, and elimination of drugs
In order to improve the delivery of drugs to the eye, it is necessary to understand how a drug is absorbed and distributed within the eye. In this project, fundamental principles in reaction kinetics and mass transfer will be applied in the development of a model of ocular drug metabolism. The model will subsequently be used to determine delivery profiles which may then be used to optimize the delivery of drugs to the eye.
Selected Publications
LM.C. Jimenez Hamann and B.A. Saville, "Enhancement of Tyrosinase Stability by Immobilization on Nylon 66", Trans I Chem E, 74(c), 47-52 (1996).S. Friedrich, B.A. Saville, Y-L. Cheng, D.S. Rootman, "Pharmacokinetic Differences between Ocular Inserts & Eyedrops", J. Ocul. Pharmacol. Ther., 12, 5-8 (1996).
C. Oh, A.J.G. Apel, B.A. Saville, Y-L. Cheng, D.S. Rootman, "Local Efficacy of Cyclosporine in Corneal Transplant Therapy", Current Eye Research, 13[5], 337-343, 1994.
R. Venugopal and B.A. Saville, "The Effect of Oxygen upon the Kinetics of Glucose Oxidase Inactivation", Can. J. Chem. Eng., 71, 917-924 (1993).