Department Calendar of Events

Jul
11
Wed
Seminar: Repairing and Regenerating Brain Tissue after a Stroke @ Donnelly Centre, Red Seminar Room (2nd Floor)
Jul 11 @ 11:00 am – 12:00 pm

Dr. Mike Modo,
Department of Radiology, University of Pittsburgh

The brain is considered to only have a limited capacity to repair damaged tissue and entirely lack the potential to regenerate lost tissue. Tissue lost after a stroke is therefore not spontaneously replaced and create a cystic cavity filled with extracellular fluid. To repair tissue damage in the peri-infarct area, we are pursuing the use of fetal-derived human neural stem cells for implantation to enhance the ongoing endogenous repair process. Although this approach has found its clinical translation, the procedure still requires optimization to ensure an appropriate delivery of cells into different tissue microenvironment. Enhancing cell survival and integration using instructive biomaterials and rehabilitation strategies are investigate to inform future clinical trials and ensure therapeutic efficacy. However, this approach does not lead to a regeneration of tissue inside the stroke cavity. To promote the invasion of endogenous brain cells into this tissue void, we are therefore investigating the implantation of inductive bioscaffolds formed out of extracellular matrix. These hydrogels attract host cells and can be efficient degraded while bridging the tissue gap. We therefore propose that this approach can induce regeneration of brain tissue in the stroke cavity. It is hope that these regenerative medicine approach will provide new therapeutic horizons for patients with stroke.

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Mike Modo, a Luxembourg-native, graduated in Psychology from Royal Holloway University of London (1997), UK, and spend 1 year as an undergraduate at the Psychology Department at McGill University (1995-1996) in Montreal, Canada. He then furthered his interests in the neural correlates underlying behavioral functions during an M.Sc. in Neuroscience (1998) at the Institute of Psychiatry at King’s College London, where he also continued his research efforts leading to a PhD in Neurosciences (2001). The main interest of Dr Modo’s research lies in the restorative neurobiology following brain damage, predominantly focused on stroke, but also in Parkinson’s and Huntington’s disease. An interdisciplinary approach is espoused that involves the use of pharmacological agents, stem cells, as well as biomaterials. A special focus lies on the development of magnetic resonance imaging (MRI) methods that allow us to guide and monitor in situ tissue engineering. Our ultimate aim is to restore a functional tissue in the brain that can support behavioral recovery.

 

Hosted by Dr. Molly Shoichet
Snacks and Refreshments will be served

Aug
14
Tue
UnERD 2018 Conference Day @ Bahen Centre
Aug 14 all-day

UnERD is the largest undergraduate research competition at the University of Toronto. It is the perfect conference for you to showcase your findings and accomplishments to like-minded students and professors. Attendees will have the chance to learn about research being done in the community and discover the opportunities available to undergraduate students.

Click HERE or important dates and details

Sep
21
Fri
Guest Lecture: Online laser monitoring of metal chloride and oxygen concentration using collinear photofragmentation and atomic absorption spectroscopy @ WB215
Sep 21 @ 3:10 pm

Jan Viljanen
PhD Candidate in Applied Optics
Tampere University of Technology, Finland

Collinear photofragmentation and atomic absorption spectroscopy (CPFAAS) is a recently developed optical method for analysing molecular concentrations and their kinetics. [1,2] The technique is based on the fragmentation of a precursor molecule and the detection of the fragment atoms via absorption spectroscopy on a common laser beam path. It has been applied to monitor concentrations of the precursors KCl and KOH in thermal conversion applications. CPFAAS studies have focused on precursor molecule concentration analysis using the maximum absorbance right after the photofragmentation. Sample lengths ranging from 1 cm to 10 m have been demonstrated in the studies [2,3]. In this work, an overview and recent development of CPFAAS is presented.

Typical CPFAAS measurement arrangement is shown in Fig 1. CPFAAS technique has been demonstrated for online monitoring of KCl, KOH, and O2 in a single particle reactor [2,3] and for KCl and PbCl2 in full-scale power plant. Typical molecular detection limits reach sub-ppm levels. The spatial resolution of the measurement can be adjusted by tuning the overlapping of the fragmenting and probing laser beams. This allows collection of localized information that is often required to support modelling work of flames and combustion processes. Online measurement of PbCl2 is a powerful demonstration of the CPFAAS technique’s ability to be applied also to monitoring of more complex molecules, such as ZnCl2, that are present in combustion processes. In addition, recent development in laser sources has brought NaCl and NaOH monitoring closer to realization.

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Jan Viljanen is finalizing his PhD in the Applied Optics research group at Tampere University of Technology, Finland. Jan has previously worked with Professor Nikolai DeMartini on the application of the techniques discussed in this talk to the release of K compounds in burning biomass particles. If you would like to meet with Jan individually, he will be available from 1 – 2:30 pm on Friday, September 21st. Please contact Professor DeMartini for details.

 

To download the lecture abstract, click HERE

Sep
28
Fri
BioZone Horizons Symposium @ Wilson Hall Rm.1017
Sep 28 @ 9:00 am – 6:00 pm

Join us for a day of presentations where members from industry and academia share their knowledge and experiences, including a poster presentation session for students to explain the potential industrial impact of their work.

Guests include:

  • Dr. Pratish Gawand
    Co-founder, CEO, Ardra Bio Inc.
  • Dr. Yaldah Azimi
    Water Design Specialist, CH2M-Jacobs
  • Dr. Scott Genin
    Head of Materials Discovery, OTI Lumionics

 

Lunch provided.

Oct
5
Fri
Special Seminar: Molecular Understanding, Design and Development of Ultra-low Fouling Zwitterionic Materials @ Donnelly Centre, Red Seminar Room (2nd Floor)
Oct 5 @ 11:00 am – 12:30 pm

Dr. Shaoyi Jiang
Department of Chemical Engineering,
University of Washington

An important challenge in many applications, ranging from drug delivery carriers to medical devices, is the prevention of nonspecific protein adsorption on surfaces. To address this challenge, our goals are twofold. First, we strive to provide a fundamental understanding of nonfouling mechanisms at the molecular level. Second, we aim to develop biocompatible and environmentally benign ultra low fouling materials based on the molecular principles we have learned. Over the last 15 years, we have demonstrated that zwitterionic and mixed charge materials and surfaces are highly resistant to nonspecific protein adsorption, cell adhesion and bacteria adhesion/biofilm formation from complex media. Both simulation and experimental results indicate that the strong hydration of zwitterionic materials is responsible for their excellent nonfouling properties. Recent results show that zwitterionic materials do not induce immunological response in blood circulation and capsule formation upon implantation and are able to preserve protein and cell bioactivity. Zwitterionic materials have been shown to be superior to poly(ethylene glycol) (PEG)-based materials for a number of biomedical and engineering applications such as drug delivery carriers, medical devices, cell preservation/expansion media, and marine coatings.
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Professor Shaoyi Jiang received his Ph.D. degree in chemical engineering from Cornell University in 1993. He was a postdoctoral fellow at the University of California, Berkeley between 1993 and 1994 and a research fellow at California Institute of Technology between 1994 and 1996 both in chemistry. He is currently the Boeing-Roundhill Professor in the Department of Chemical Engineering and an adjunct professor of Bioengineering at the University of Washington, Seattle. He was a visiting professor in the Department of Chemical Engineering at MIT with Prof. Robert Langer in 2007. He is a senior editor for Langmuir, a fellow of the American Institute of Chemical Engineers (AIChE), a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a member of Washington Academy of Sciences. He received the Braskem Award for Excellence in Materials Engineering and Science, AIChE (2017). His research focuses on the molecular understanding, design and development of zwitterionic-based functional materials for biomedical and engineering applications.

 

Hosted by Dr. Molly Shoichet
Snacks and Refreshments will be served

 

Oct
15
Mon
The Problem with Persistence: PFAS as Extreme Emerging Water Contaminant @ Sanford Fleming SF3201
Oct 15 @ 4:10 pm

Dr. Carla Ng
Departments of Civil & Environmental Engineering, & Chemical & Petroleum Engineering
UNIVERSITY OF PITTSBURGH

Per and polyfluorinated alkyl substances (PFAS) comprise a large group of industrial chemicals that have become pervasive environmental contaminants. Among them, long-chain perfluorinated alkyl acids are now recognized as extremely persistent, bioavailable, and bioaccumulative substances. Growing concern regarding their toxicological effects has led to (largely voluntary) phaseouts in the US and Europe. Short-chain acids were suggested as immediate drop-in replacements because they do not bioaccumulate and are therefore considered less toxic. Yet emerging data on the potential toxicity of even very low levels of certain PFAS is driving regional “action levels” in drinking water in the part per trillion range.

At the same time, a wide variety of “alternative PFAS” have increased production to fill market demand. Thousands of different PFAS, with a variety of chain lengths, degrees of fluorination, and functional groups are now used in industries ranging from fire fighting to industrial processing to personal care products to food packaging. Very little is known about the bioaccumulation potential and toxic effects of these replacement compounds.

In this seminar, we will explore why current risk assessment paradigms and water treatment approaches fail to adequately capture or mitigate the risks posed by PFAS and discuss strategies for addressing this pressing global contamination problem.

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Dr. Carla Ng is an Assistant Professor in Civil and Environmental Engineering at the University of Pittsburgh, with a secondary appointment in Chemical & Petroleum Engineering.  She received her PhD in Chemical & Biological Engineering from Northwestern University in 2008. The research in Dr. Ng’s group focuses on the development of models for the fate of chemicals in organisms and ecosystems, at the intersection of chemistry, biology and engineering. Active research areas include the development of mechanistic models for the bioaccumulation of emerging contaminants in organisms, tracking the fate of legacy and current-use pesticides in tropical environments, and exploring the role of the industrial food system on the fate of environmental contaminants, with implications for human exposure.

Oct
17
Wed
LLE: Irving O. Shoichet Distinguished Lecture | Giving New Life to Materials for Energy, the Environment, and Medicine @ Wallberg WB116
Oct 17 @ 12:00 pm – 1:00 pm


ANGELA BELCHER

Massachusetts Institute of Technology

Giving New Life to Materials for Energy, the Environment, and Medicine 

Organisms have been making exquisite inorganic materials for over 500 million years. Although these materials have many desired physical properties such as strength, regularity, and environmentally benign processing, the types of materials that organisms have evolved to work with are limited. However, there are many properties of living systems that could be potentially harnessed by researchers to make advanced technologies that are smarter, more adaptable, and that are synthesized to be compatible with the environment. One approach to designing future technologies which have some of the properties that living organisms use so well, is to evolve organisms to work with a more diverse set of building blocks. The goal is to have a DNA sequence that codes for the synthesis and assembly of any inorganic material or device. We have been successful in using evolutionarily selected peptides to control physical properties of nanocrystals and subsequently use molecular recognition and self-assembly to design biological hybrid multidimensional materials. These materials could be designed to address many scientific and technological problems in electronics, environmental remediation, medicine, and energy applications. Currently we are using this technology to design new methods for building batteries, fuel cells, solar cells, carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging. This talk will address conditions under which organisms first evolved to make materials and scientific approaches to move beyond naturally evolved materials to genetically imprint advanced technologies with examples in lithium and sodium ion batteries, lithium-air batteries, environmental clean-up and ovarian cancer imaging and treatment.
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Angela Belcher is a biological and materials engineer with expertise in biomaterials, biomolecular materials, organic-inorganic interfaces and solid-state chemistry and devices. Her primary research focus is evolving new materials for energy, electronics, the environment, and medicine. She received her B.S. in Creative Studies from The University of California, Santa Barbara. She earned a Ph.D. in inorganic chemistry at UCSB. Following with her postdoctoral research in electrical engineering at UCSB. She now holds the James Mason Crafts Professor of Biological Engineering and Materials Engineering at MIT. She is faculty in the Department of Biological Engineering, Materials Science and Engineering and the Koch Institute of Integrative Cancer Research. She teaches undergraduate subjects in material sciences and engineering and biological engineering. In 2002, she founded the company Cambrios Technologies, Inc., and in 2007 she founded Siluria Technologies, Inc. Some recent awards include the 2013 $500,000 Lemelson-MIT Prize for her Inventions, 2010 Eni Prize for Renewable and Non-conventional Energy, in 2009 Rolling Stone Magazine listed her as one of the top 100 people changing the country. In 2007, Time Magazine named her a “Hero”- for her research related to Climate Change. In 2004, she received the Four Star General Recognition Award (US Army) for significant contribution to army transformation. In 2000, she was awarded the Presidential Early Career Award in Science and Engineering (PECASE). She was named Research Leader of the Year by Scientific American, and is a MacArthur Fellow, a Packard Fellow, a NAI (National Academy of Inventors) Fellow, an Alfred P. Sloan Fellow, a NAE (National Acedemy of Engineers) Fellow, and a member of American Academy of Arts and Sciences.

 

Download the lecture poster HERE

For more information on Lectures at the Leading Edge 2018-19 click HERE.

Oct
28
Sun
CSChE 2018 – the 29th Inter-American Congress of Chemical Engineering incorporating the 68th Canadian Chemical Engineering Conference @ Sheraton Centre
Oct 28 – Oct 31 all-day


Welcome to the 29th Inter-American Congress of Chemical Engineering incorporating the 68th Canadian Chemical Engineering Conference, to be held in Toronto, Ontario, October 28-31, 2018. This international event is co-organized by the University of Toronto, Ryerson University and the Canadian Society for Chemical Engineering.  Over 80 professionals from academia, industry, and government within Canada and abroad support the organizing committee. We anticipate up to 1,500 delegates from over 40 countries will attend the conference.

With the theme – “Engineering for a Healthy and Sustainable Planet”, the conference aims to address the big challenges that the world is facing in the area of human health, sustainable energy, natural resources, globalization and the environment.  Central to the conference is the technical program that consists of over 1,000 oral and poster presentations, including five plenary lectures given by distinguished speakers, including the winners of the R.S. Jane Memorial Award, the J.S. Oldshue Award and the Montreal Medal.  There are seven international symposia on topical subjects, with three to honor internationally renowned Canadian pioneers in lignocellulosic resources David Goring, environmental science Don Mackay and biomedical engineering Mike Sefton.  Moreover, ten technical tracks are organized, reflecting the diversity of chemical engineering discipline and showcasing the advances in traditional and emerging chemical engineering fields.  In addition, six special sessions are created, including one on “Modern Engineering Education” and two led by industry champions, on “Process Safety Management” and “Products and Processes for a Circular Economy”, respectively.  Unique to this conference is the “Chemical Engineering Research in Latin America” –  a session to be held in Portuguese/Spanish.  The “Emerging Leaders Forum” will feature four early career researchers, recognizing their contributions, vision and leadership in their respective fields.  A rich and wholesome student program is developed for both undergraduate and graduate students, consisting of eight events ranging from 3-minute pitch and Hatch plant design competitions to a workshop on early career publishing.

Learn More

Nov
12
Mon
LLE: 2018-19 AEESP Distinguished Lecture: Can Engineering Controls Shape the Drinking Water Microbiome and Reduce the Risk of Opportunistic Infections? @ Bahen Centre BA1170
Nov 12 @ 1:00 pm – 2:00 pm

Co-hosted with CivMin, and Engineering Departments at Ryerson, and York

LUTGARDE RASKIN
University of Michigan

Can engineering controls shape the drinking water microbiome and reduce the risk of opportunistic infections? 

Biological treatment processes and particularly biofiltration have gained tremendous popularity in the drinking water field over the past decade. However, we do not yet understand how biofiltration, disinfection, and transport of treated water through distribution systems and building plumbing influence tap water and human microbiomes. Most microbes in biofilters mediate positive impacts through removal of contaminants, but others have the potential to cause disease. In high-income countries, the risk of waterborne infection is often due to exposure to opportunistic pathogens, such as Legionella pneumophila and nontuberculous mycobacteria. This presentation will show that these microbes, present in source water microbiomes, are only partially removed and sometimes are selected for by current treatment practices and therefore become integrated in the diverse microbial communities in drinking water. Waterborne infections by these microbes mainly affect immunocompromised individuals, a rapidly expanding subset of the population, and result primarily from inhalation of aerosols. These findings call for an increased understanding of how drinking water aerosols impact our respiratory tract microbiomes. We have begun to address this challenge by focusing on cystic fibrosis, a condition known to predispose individuals to polymicrobial respiratory tract infection. The presentation will conclude by discussing steps water quality engineers and drinking water utilities can take to reduce risk of opportunistic infections while maintaining drinking water treatment objectives.
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LUTGARDE RASKIN is the Altarum/ERIM Russell O’Neal Professor of Environmental Engineering and one of four faculty members of the University of Michigan Environmental Biotechnology group. She is inspired by the complexity of the microbial world and the astonishing progress we have made in the field of microbial ecology over the past few decades. This progress continuously motivates her to rethink engineered systems so we can better harness the power of microorganisms to treat water and recover resources from waste stream.

Lutgarde strives to understand and improve various aspects of the engineered water cycle microbiome to improve human health using sustainable design approaches. Her research places particular focus on (i) water and energy recovery from waste streams and energy crops, and (ii) drinking water systems including biofiltration, disinfection, distribution and premise plumbing.

 

Download the lecture poster HERE

For more information on Lectures at the Leading Edge 2018-19 click HERE.

Nov
16
Fri
BioZone Mass Spectrometry User Meeting @ Wallberg Building WB407
Nov 16 @ 12:00 pm – 5:00 pm